FLLL 32
FLLL-32
CAS: 1226895-15-3
Molecular Formula: C28H32O6
FLLL 32 - Names and Identifiers
FLLL 32 - Physico-chemical Properties
| Molecular Formula | C28H32O6 |
| Molar Mass | 464.55008 |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| In vitro study | FLLL32 down-regulates STAT3 phosphorylation and DNA binding activity in MDA-MB-231 breast cancer and PANC-1 pancreatic cancer cells. FLLL32 inhibited colony formation and cell invasion in MDA-MB-231 cells. For human multiple myeloma, glioblastoma, hepatoma, and colorectal cancer, FLLL32 also results in inhibition of cell proliferation and induction of caspase-3 and PARP cleavage. |
| In vivo study | FLLL32 (50 mg/kg, I. p.) significantly reduced tumor burden in MDA-MB-231 xenografted mice. FLLL32 (50 mg/kg, I. p.) also inhibited tumor growth by targeting STAT3 in OS-33 osteosarcoma cell xenografted mice. |
FLLL 32 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.153 ml | 10.763 ml | 21.526 ml |
| 5 mM | 0.431 ml | 2.153 ml | 4.305 ml |
| 10 mM | 0.215 ml | 1.076 ml | 2.153 ml |
| 5 mM | 0.043 ml | 0.215 ml | 0.431 ml |
Last Update：2024-01-02 23:10:35
FLLL 32 - Introduction
FLLL-32 is a chemical substance whose chemical name is 4-[(4-chloroanilinyl) oxy] benzoic acid. The following is a description of the nature, use, preparation and safety information of the FLLL-32:
Nature:
-Appearance: The FLLL-32 is a white crystalline solid.
-Solubility: FLLL-32 are soluble in many common solvents.
-Melting point: The melting point of the FLLL-32 is about 220-222°C.
Use:
-Inhibition of activated signal transducer and activator of transcription 3(STAT3):FLLL-32 can inhibit the activity of STAT3, thereby interfering with the signal transmission pathway in the cell, and has potential anti-cancer activity.
Preparation Method:
-The preparation method of FLLL-32 is more complex and professional, involving a multi-step reaction and purification process. Generally, it is prepared through a series of reaction steps using related chemical synthesis techniques and established synthetic routes.
Safety Information:
- FLLL-32 is a chemical substance and should be handled in accordance with relevant safety procedures. When using or operating the FLLL-32, care should be taken to wear appropriate protective equipment, such as gloves, glasses and laboratory coats.
-Avoid inhaling FLLL-32 dust or gas, and avoid contact with skin and eyes.
-Before use, conduct a safety assessment of the FLLL-32 and follow relevant operating and storage guidelines.
-Please note that the above information is for reference only. Before using or handling FLLL-32, it is recommended to consult accurate safety data sheets and chemical instructions, and to follow relevant safe handling and management practices.
Nature:
-Appearance: The FLLL-32 is a white crystalline solid.
-Solubility: FLLL-32 are soluble in many common solvents.
-Melting point: The melting point of the FLLL-32 is about 220-222°C.
Use:
-Inhibition of activated signal transducer and activator of transcription 3(STAT3):FLLL-32 can inhibit the activity of STAT3, thereby interfering with the signal transmission pathway in the cell, and has potential anti-cancer activity.
Preparation Method:
-The preparation method of FLLL-32 is more complex and professional, involving a multi-step reaction and purification process. Generally, it is prepared through a series of reaction steps using related chemical synthesis techniques and established synthetic routes.
Safety Information:
- FLLL-32 is a chemical substance and should be handled in accordance with relevant safety procedures. When using or operating the FLLL-32, care should be taken to wear appropriate protective equipment, such as gloves, glasses and laboratory coats.
-Avoid inhaling FLLL-32 dust or gas, and avoid contact with skin and eyes.
-Before use, conduct a safety assessment of the FLLL-32 and follow relevant operating and storage guidelines.
-Please note that the above information is for reference only. Before using or handling FLLL-32, it is recommended to consult accurate safety data sheets and chemical instructions, and to follow relevant safe handling and management practices.
Last Update：2024-04-09 15:16:34
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